Design strategy for protein stability: stable local conformation in consistency with the global conformation
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چکیده
منابع مشابه
COMMUNICATION Global and Local Conformation of human IgG Antibody Variants Rationalises Loss of Thermodynamic Stability
Immunoglobulin G (IgG) monoclonal antibodies (mAbs) are a major class of medicines, with high specificity and affinity towards targets spanning many disease areas. The antibody Fc (fragment crystallisable) region is a vital component of existing antibody therapeutics as well as many next generation biologic medicines. The size and complexity of these molecules make them difficult to characteris...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1993
ISSN: 0108-7673
DOI: 10.1107/s0108767378095768